Scientist I, Computational Discovery
Company: Disability Solutions
Location: Boston
Posted on: October 19, 2024
Job Description:
About the Job
The Scientist, Cancer Genomics position sits within the Research &
Early Development team in the Product Development group and is
responsible for working on discovery projects to establish
correlations between genotype and phenotype. Using a variety of
phenotypic measures, the role supports the discovery of novel
biomarkers, drug sensitivity, resistance signatures, and genomic
alterations involved in tumorigenesis. The primary functions rely
on leveraging FoundationCORE, FMI's 300,000+ tumor sample dataset,
to investigate novel cancer gene alterations (including annotation
using publicly-available online resources such as UniProt and The
Cancer Genome Atlas Program) and prepare scientific
manuscripts.--
--
Key Responsibilities
- Develop and evaluate potential biomarkers using
FoundationCORE.
- Determine when statistical analysis is needed and apply the
analysis.
- Use a computer cluster to analyze genomic signatures on
historical samples.
- Communicate with Biopharma partners and internal departments as
needed to define specifics of cancer mutations and other related
scientific queries.
- Perform queries for Biopharma partners and return
results.
- Utilize cancer genomics expertise to investigate genomic
mechanisms of oncogenesis.
- Integrate appropriate clinical data with Next-Generation
Sequencing (NGS) output.
- Work collaboratively with internal colleagues to refine
analysis algorithms and methods.
- Contribute scientific expertise to broader projects within the
Research and Development team.
- Other duties as assigned.
--
Qualifications
Basic Qualifications:
- Bachelor's degree in related field and 3+ years of research
experience preferred in the life sciences industry; OR,
- Master's and 2+ research experience preferred in the life
sciences industry; OR,
- PhD and no experience
Preferred Qualifications:
- 1+ years of industry or post-doctorate experience within Cancer
Biology, Bioinformatics, Biochemistry, or another related life
science
- 1+ years of industry or post-doctorate research experience with
cancer genomics and/or next-generation sequencing
principles
- Familiarity with one or more of the following scientific
computing languages: Python, R, Matlab, or Java
- Familiarity with clinical nomenclature including stage, grade,
ECOG, and the patient journey in oncology
- Familiarity with basic statistics
- Experience working with publicly available datasets, such as
TCGA
- Ability to analyze and critically interpret scientific
literature
- Effective oral and written communication skill
- Excellent writing skills and the desire to contribute to
scientific manuscripts and abstracts
- Reliability, high ethical standards and integrity
- Translational research experience
- Understanding of HIPAA and importance of privacy of patient
data
- Commitment to FMI values: patients, innovation, collaboration,
and passion
#LI-Hybrid
Keywords: Disability Solutions, Nantucket , Scientist I, Computational Discovery, Other , Boston, Massachusetts
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